There are ways but they are quite difficult. The Sync or Connect apps offer that, although I think they aren’t updated often iirc. Some exceedingly few instances have defederated from lemmy.ml, but none of the major ones. You can also get into customized uBlock Origin filtering rules, if you want…

Or just switch to PieFed, which has tons of features that Lemmy lacks. Like seriously, just tons and tons of them, and more keep being added practically weekly. Lemmy can or will not keep up, so it will fall behind and PieFed continue to pull ahead, watch and see. https://piefed.social/auth/instance_chooser